Recent Publications

L. Ferretti, A. Ledda, T. Wiehe, G. Achaz and S.E. Ramos-Onsins (2017)

Decomposing the Site Frequency Spectrum: The Impact of Tree Topology on Neutrality Tests

 Genetics, q-bio.GN


T. Pauli, L. Vedder, D. Dowling, M. Petersen, K. Meusemann, A. Donath, R.S. Peters, L. Podsiadlowski, C. Mayer, S. Liu, X. Zhou, P. Heger, T. Wiehe, L. Hering, G. Mayer, B. Misof, O. Niehuis (2016)

Transcriptomic data from panarthropods shed new light on the evolution of insulator binding proteins in insects

 BMC Genomics, 17:861


P. Schiffer, J. Gravemeyer, M. Rauscher, T. Wiehe (2016)

Ultra large gene families: a matter of adaptation or genomic parasites?

 Life 2016, 6(3),32


L. Ferretti, A. Klassmann, T. Wiehe, S.E. Ramos-Onsins, G. Achaz (2016)

The expected neutal frequency spectrum of two linked sites


A. Kraemer-Eis, L. Ferretti, P. Schiffer, P. Heger, T. Wiehe (2016)

The developmental genetic toolkit shared by bilaterian crown clades after a billion years of divergence



A. Ledda, G. Achaz, T. Wiehe, L. Ferretti

Decomposing the site frequency spectrum: the impact of tree topology on neutrality tests



K. Howe, P.H. Schiffer, J. Zielinski, T. Wiehe, G.K. Laird, J. Marioni, O. Soylemez, F. Kondrashov, M. Leptin (2015)

Structure and evolutionary history of a large family of NLR proteins in the zebrafish

 Open Biol. 2016 6


P. Heger, T. Wiehe (2014)

New tools in the box: an evolutionary synopsis of chromatin insulators.

 Trends in Genetics 30(5):161-71


F. Disanto, T. Wiehe (2014)

On the sub-permutations of pattern avoiding permutations

 Discrete Mathematics 337:127


M. Rafajlovic, A. Klassmann, A. Eriksson, T. Wiehe, B. Mehlig (2014)

Demography-adjusted tests of neutrality based on genome-wide SNP data

 Theor. Pop. Biol. 95:1


P.H. Schiffer, M. Kroiher, C. Kraus, G.D. Koutsovoulos, S. Kumar, J.I. Camps, N.A. Nsah, D. Stappert, K. Morris, P. Heger, J. Altmüller, P. Frommolt, P. Nürnberg, W.K. Thomas, M.L. Blaxter, E. Schierenberg (2013)

The genome of Romanomermis culicivorax: revealing fundamental changes in the core developmental genetic toolkit in Nematoda.

 BMC Genomics. 14:923.


F. Disanto, A. Schlizio, T. Wiehe (2013)

Yule-generated trees constrained by node imbalance

Math Biosci  246:139–147


P. Heger, R. George and T. Wiehe (2013)

Successive gain of insulator proteins in arthropod evolution

Evolution  67:2945–2956


H. Li, T. Wiehe (2013)

Coalescent tree imbalance and a simple test for selective sweeps based on microsatellite variation

 Plos Comput Biol. 9(5):e1003060


L. Ferretti, F. Disanto, T. Wiehe (2013)

The effect of single recombination events on coalescent tree height and shape

 PloS One 8(4):e60123


F. Disanto, T. Wiehe (2013)

Exact enumeration of cherries and pitchforks in ranked trees under the coalescent model

 Math Biosci. 242:195-200 4pp


P. Heger, B. Marin, M. Bartkuhn, E. Schierenberg, T. Wiehe (2012)

The chromatin insulator CTCF and the emergence of metazoan diversity

 PNAS 109:17507


F. Disanto, T. Wiehe (2012)

Some instances of a sub-permutation problem on pattern avoiding permutations



S. Uhrig, O. Coutelle, T. Wiehe, L. Perabo, M. Hallek, H. Büning (2011)

Successful target cell transduction of capsid-engineered rAAV vectord requires clathrin-dependent endocytosis

 Gene Ther.  19(2):210-8


D. Richardson and T. Wiehe (2009)

Properties of sequence conservation in upstream regulatory and protein coding regions among paralogs in Arabidopsis thaliana

Lecture Notes in Computer Science: Lecture Notes in Bioinformatics, Vol. 5817, Ciccarelli, F.; Miklos, I. (Eds.) 2009, pp 217-218, Springer Berlin. Abstract


B. Haubold, P. Pfaffelhuber, D. Domazet-Loso and T. Wiehe (2009)

Estimating mutation distances from unaligned genomes

 J Comput Biol. 16(10):1487-1500


Y. Kim and T. Wiehe (2008)

Simulation of DNA sequence evolution under models of recent directional selection

 Brief Bioinform. 10(1):84-96


B. Haubold, M. Domazet-Loso and T. Wiehe (2008)

An alignment-free distance measure for closely related genomes

Lecture Notes in Computer Science: Lecture Notes in Bioinformatics, Vol. 5267, Nelson, C.; Vialette, S. (Eds.) 2008, X, 265 p., Springer Berlin. Abstract


M. Teschke, O. Mukabayire, T. Wiehe and D. Tautz (2008)

Identification of selective sweeps in closely related populations of the house mouse based on microsatellite scans

 Genetics. 180:1537-1545


D. Živkovi? and T. Wiehe (2008)

Second order moments of segregating sites under variable population size

 Genetics. 180:341-357


M. Stephan, F. Möller, T. Wiehe, J. Kleffe (2007)

Self-alignments to detect mutually exclusive exon usage

 In Silico Biol. 7(6):613-621


I. Vukusic, S. Nagaraja Grellscheid, T. Wiehe (2007)

Applying genetic programming to the prediction of alternative mRNA splice variants

 Genomics. 89(4):471-479


M. Thomas, F. Möller, T. Wiehe and D. Tautz (2007)

A pooling approach to detect signatures of selective sweeps in genome scans using microsatellites

 Mol Ecol Notes. 7(3):400-403


T. Wiehe, V. Nolte, D. Živkovi and C. Schlötterer (2007)

Identification of selective sweeps using a dynamically adjusted number of linked microsatellites

 Genetics. 175(1):207-218


B. Haubold, T. Wiehe (2006)

How repetitive are genomes?

 BMC Bioinformatics. 7:541


N. Pierstorff, C. Bergman and T. Wiehe (2006)

Identifying cis-regulatory modules by combining comparative and compositional analysis of DNA

 Bioinformatics. 22(23):2858-2864


B. Haubold and T. Wiehe (2006)

Introduction to Computational Biology. An Evolutionary Approach. 

Textbook, 328p. Birkhauser, Basel.  Link


B. Haubold, N. Piersdorff, F. Möller and T. Wiehe (2005)

Genome comparison without alignment using shortest unique substrings

 BMC Bioinformatics. 6:123


M. Thomas, S. Ihle, I. Ravaoarimanana, S. Krächter, T. Wiehe and D. Tautz (2005)

Microsatellite variability in wild populations of the house mouse is not influenced by differences in chromosomal recombination rates

 Biol J Linn Soc Lond. 84(3):629-635