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Recent Publications

P.-C. Venter, F. Nitsche, A. Domonell, P. Heger, H. Arndt (2017)
The Protistan Microbiome of Grassland Soil: Diversity in the Mesoscale
doi: https://doi.org/10.1016/j.protis.2017.03.005

L. Ferretti, A. Ledda, T. Wiehe, G. Achaz and S.E. Ramos-Onsins (2017)
Decomposing the Site Frequency Spectrum: The Impact of Tree Topology on Neutrality Tests
 Genetics, q-bio.GN 

T. Pauli, L. Vedder, D. Dowling, M. Petersen, K. Meusemann, A. Donath, R.S. Peters, L. Podsiadlowski, C. Mayer, S. Liu, X. Zhou, P. Heger, T. Wiehe, L. Hering, G. Mayer, B. Misof, O. Niehuis (2016)
Transcriptomic data from panarthropods shed new light on the evolution of insulator binding proteins in insects
 BMC Genomics, 17:861 

P. Schiffer, J. Gravemeyer, M. Rauscher, T. Wiehe (2016)
Ultra large gene families: a matter of adaptation or genomic parasites?
 Life 2016, 6(3),32

L. Ferretti, A. Klassmann, T. Wiehe, S.E. Ramos-Onsins, G. Achaz (2016)
The expected neutal frequency spectrum of two linked sites
 http://arxiv.org/abs/1604.06713

A. Kraemer-Eis, L. Ferretti, P. Schiffer, P. Heger, T. Wiehe (2016)
The developmental genetic toolkit shared by bilaterian crown clades after a billion years of divergence
 doi: http://dx.doi.org/10.1101/041806

Older Publications

A. Ledda, G. Achaz, T. Wiehe, L. Ferretti (2015)
Decomposing the site frequency spectrum: the impact of tree topology on neutrality tests
 arXiv:1510.06748

K. Howe, P.H. Schiffer, J. Zielinski, T. Wiehe, G.K. Laird, J. Marioni, O. Soylemez, F. Kondrashov, M. Leptin (2015)
Structure and evolutionary history of a large family of NLR proteins in the zebrafish
 Open Biol. 2016 6

P. Heger, T. Wiehe (2014)
New tools in the box: an evolutionary synopsis of chromatin insulators.
 Trends in Genetics 30(5):161-71

F. Disanto, T. Wiehe (2014)
On the sub-permutations of pattern avoiding permutations
 Discrete Mathematics 337:127

M. Rafajlovic, A. Klassmann, A. Eriksson, T. Wiehe, B. Mehlig (2014)
Demography-adjusted tests of neutrality based on genome-wide SNP data
 Theor. Pop. Biol. 95:1

P.H. Schiffer, M. Kroiher, C. Kraus, G.D. Koutsovoulos, S. Kumar, J.I. Camps, N.A. Nsah, D. Stappert, K. Morris, P. Heger, J. Altmüller, P. Frommolt, P. Nürnberg, W.K. Thomas, M.L. Blaxter, E. Schierenberg (2013)
The genome of Romanomermis culicivorax: revealing fundamental changes in the core developmental genetic toolkit in Nematoda.
 BMC Genomics. 14:923.

F. Disanto, A. Schlizio, T. Wiehe (2013)
Yule-generated trees constrained by node imbalance
Math Biosci  246:139–147

P. Heger, R. George and T. Wiehe (2013)
Successive gain of insulator proteins in arthropod evolution
Evolution  67:2945–2956

H. Li, T. Wiehe (2013)
Coalescent tree imbalance and a simple test for selective sweeps based on microsatellite variation
 Plos Comput Biol. 9(5):e1003060

L. Ferretti, F. Disanto, T. Wiehe (2013)
The effect of single recombination events on coalescent tree height and shape
 PloS One 8(4):e60123

F. Disanto, T. Wiehe (2013)
Exact enumeration of cherries and pitchforks in ranked trees under the coalescent model
 Math Biosci. 242:195-200 4pp

P. Heger, B. Marin, M. Bartkuhn, E. Schierenberg, T. Wiehe (2012)
The chromatin insulator CTCF and the emergence of metazoan diversity
 PNAS 109:17507

F. Disanto, T. Wiehe (2012)
Some instances of a sub-permutation problem on pattern avoiding permutations
 arXiv:1210.6908

S. Uhrig, O. Coutelle, T. Wiehe, L. Perabo, M. Hallek, H. Büning (2011)
Successful target cell transduction of capsid-engineered rAAV vectord requires clathrin-dependent endocytosis
 Gene Ther.  19(2):210-8

D. Richardson and T. Wiehe (2009)
Properties of sequence conservation in upstream regulatory and protein coding regions among paralogs in Arabidopsis thaliana
Lecture Notes in Computer Science: Lecture Notes in Bioinformatics, Vol. 5817, Ciccarelli, F.; Miklos, I. (Eds.) 2009, pp 217-218, Springer Berlin. Abstract

B. Haubold, P. Pfaffelhuber, D. Domazet-Loso and T. Wiehe (2009)
Estimating mutation distances from unaligned genomes
 J Comput Biol. 16(10):1487-1500

Y. Kim and T. Wiehe (2008)
Simulation of DNA sequence evolution under models of recent directional selection
 Brief Bioinform. 10(1):84-96

B. Haubold, M. Domazet-Loso and T. Wiehe (2008)
An alignment-free distance measure for closely related genomes
Lecture Notes in Computer Science: Lecture Notes in Bioinformatics, Vol. 5267, Nelson, C.; Vialette, S. (Eds.) 2008, X, 265 p., Springer Berlin. Abstract

M. Teschke, O. Mukabayire, T. Wiehe and D. Tautz (2008)
Identification of selective sweeps in closely related populations of the house mouse based on microsatellite scans
 Genetics. 180:1537-1545

D. Živkovi? and T. Wiehe (2008)
Second order moments of segregating sites under variable population size
 Genetics. 180:341-357

M. Stephan, F. Möller, T. Wiehe, J. Kleffe (2007)
Self-alignments to detect mutually exclusive exon usage
 In Silico Biol. 7(6):613-621

I. Vukusic, S. Nagaraja Grellscheid, T. Wiehe (2007)
Applying genetic programming to the prediction of alternative mRNA splice variants
 Genomics. 89(4):471-479

M. Thomas, F. Möller, T. Wiehe and D. Tautz (2007)
A pooling approach to detect signatures of selective sweeps in genome scans using microsatellites
 Mol Ecol Notes. 7(3):400-403

T. Wiehe, V. Nolte, D. Živkovi and C. Schlötterer (2007)
Identification of selective sweeps using a dynamically adjusted number of linked microsatellites
 Genetics. 175(1):207-218

B. Haubold, T. Wiehe (2006)
How repetitive are genomes?
 BMC Bioinformatics. 7:541

N. Pierstorff, C. Bergman and T. Wiehe (2006)
Identifying cis-regulatory modules by combining comparative and compositional analysis of DNA
 Bioinformatics. 22(23):2858-2864

B. Haubold and T. Wiehe (2006)
Introduction to Computational Biology. An Evolutionary Approach.
Textbook, 328p. Birkhauser, Basel.  Link

B. Haubold, N. Piersdorff, F. Möller and T. Wiehe (2005)
Genome comparison without alignment using shortest unique substrings
 BMC Bioinformatics. 6:123

M. Thomas, S. Ihle, I. Ravaoarimanana, S. Krächter, T. Wiehe and D. Tautz (2005)
Microsatellite variability in wild populations of the house mouse is not influenced by differences in chromosomal recombination rates
 Biol J Linn Soc Lond. 84(3):629-635