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Recent Publications

Jabbari K, Heger P, Sharma R, Wiehe T (2018)
The diverging routes of BORIS and CTCF: An interactomic and phylogenomic analysis

Life, 8(1), 4; doi:10.3390/life8010004

Bobbili D, Lal D, May P, Reinthaler E, Jabbari K, Thiele H, Nothnagel M, Jurkowski W, Feucht M, Nürnberg P, Lerche H, Zimprich F, Krause R,  Neubauer B, Reinthaler E, Zimprich F, Feucht M , Steinböck H, Neophytou B, Geldner J, Gruber-Sedlmayr U, Haberlandt E, Ronen G, Altmüller J, Sander T, Thiele H, Krause R, May P, Balling R,  Neubauer B (2018)
Exome-wide analysis of mutational burden in patients with typical and atypical Rolandic epilepsy
Eur J Hum Genet;26(2); doi:10.1038/s41431-017-0034-x

Ferretti L, Klassmann A, Raineri E, Wiehe T, Ramos-Onsins SE, Achaz G (2018)
The expected neutral frequency spectrum of linked sites

Zheng Y, Janke A. (2018)
Gene flow analysis method, the D-statistic, is robust in a wide parameter space

BMC Bioinformatics 19(10), doi:10.1186/s12859-017-2002-4

Nilsson MA, Zheng Y, Kumar V, Phillips MJ, Janka A. (2018)
Speciation Generates Mosaic Genomes in Kangaroos

Genome Biol Evol 10 (1):33-44

Klassmann A, Ferretti L (2018)
The third moments of the site frequency spectrum
Theoretical Population Biology 120; doi:10.1101/109579

Yang Y, Li J, Wiehe T, Li H (2017)
Detecting recent positive selection with a single locus test bi-partitioning the coalescent tree
Genetics 208(4); doi:10.1534/genetics.117.300401

Suurväli J, Boudinot P, Kanellopoulos J, Boudinot SR (2017)
P2X4: A fast and sensitive purinergic receptor
Biomedical Journal 40(5); doi:10.1016/

Venter P-C, Nitsche F, Domonell A, Heger P, Arndt H (2017)
The Protistan Microbiome of Grassland Soil: Diversity in the Mesoscale
Protist 168(5); doi:10.1016/j.protis.2017.03.005

Ferretti L, Ledda A, Wiehe T, Achaz G, Ramos-Onsins SE (2017)
Decomposing the Site Frequency Spectrum: The Impact of Tree Topology on Neutrality Tests
Genetics, q-bio.GN 

Pauli T, Vedder L, Dowling D, Petersen M, Meusemann K, Donath A, Peters RS, Podsiadlowski Mayer LC, Liu S, X. Zhou, Heger P, Wiehe T, Hering L, Mayer G, Misof B, Niehuis O (2016)
Transcriptomic data from panarthropods shed new light on the evolution of insulator binding proteins in insects
BMC Genomics, 17:861 

Schiffer P, Gravemeyer J, Rauscher M, Wiehe T (2016)
Ultra large gene families: a matter of adaptation or genomic parasites?
Life 2016, 6(3),32

Kraemer-Eis A, Ferretti L, Schiffer P, Heger P, Wiehe T (2016)
The developmental genetic toolkit shared by bilaterian crown clades after a billion years of divergence

Older Publications

Ledda A, Achaz G, Wiehe T, Ferretti L (2015)
Decomposing the site frequency spectrum: the impact of tree topology on neutrality tests

Howe K, Schiffer PH, Zielinski J, Wiehe T, Laird GK, Marioni J, Soylemez O, Kondrashov F, Leptin M (2015)
Structure and evolutionary history of a large family of NLR proteins in the zebrafish
Open Biol. 2016 6

Heger P, Wiehe T (2014)
New tools in the box: an evolutionary synopsis of chromatin insulators.
Trends in Genetics 30(5):161-71

Disanto F, Wiehe T (2014)
On the sub-permutations of pattern avoiding permutations
Discrete Mathematics 337:127

Rafajlovic M, Klassmann A, Eriksson A, Wiehe T, Mehlig B (2014)
Demography-adjusted tests of neutrality based on genome-wide SNP data
Theor. Pop. Biol. 95:1

Schiffer PH, Kroiher M, Kraus C, Koutsovoulos GD, Kumar S, Camps JI, Nsah NA, Stappert D, Morris K, Heger P, Altmüller J, Frommolt P, Nürnberg P, Thomas WK, laxter ML, Schierenberg E (2013)
The genome of Romanomermis culicivorax: revealing fundamental changes in the core developmental genetic toolkit in Nematoda.
BMC Genomics. 14:923.

Disanto F, Schlizio A, Wiehe T (2013)
Yule-generated trees constrained by node imbalance
Math Biosci 246:139–147

Heger P, George R, Wiehe T (2013)
Successive gain of insulator proteins in arthropod evolution
Evolution 67:2945–2956

Li H, Wiehe T (2013)
Coalescent tree imbalance and a simple test for selective sweeps based on microsatellite variation
Plos Comput Biol. 9(5):e1003060

Ferretti L, Disanto F, Wiehe T (2013)
The effect of single recombination events on coalescent tree height and shape
PloS One 8(4):e60123

Disanto F, Wiehe T (2013)
Exact enumeration of cherries and pitchforks in ranked trees under the coalescent model
Math Biosci. 242:195-2004pp

Heger P, Marin B, Bartkuhn M, Schierenberg E, Wiehe T (2012)
The chromatin insulator CTCF and the emergence of metazoan diversity
PNAS 109:17507

Disanto F, Wiehe T (2012)
Some instances of a sub-permutation problem on pattern avoiding permutations

Uhrig S, Coutelle O, Wiehe T, Perabo L, Hallek M, Büning H (2011)
Successful target cell transduction of capsid-engineered rAAV vectord requires clathrin-dependent endocytosis
Gene Ther. 19(2)

Richardson D, Wiehe T (2009)
Properties of sequence conservation in upstream regulatory and protein coding regions among paralogs in Arabidopsis thaliana
Lecture Notes in Computer Science: Lecture Notes in Bioinformatics, Vol. 5817, Ciccarelli, F.; Miklos, I. (Eds.) 2009, Springer Berlin. Abstract

Haubold B, Pfaffelhuber P, Domazet-Loso D, Wiehe T (2009)
Estimating mutation distances from unaligned genomes
J Comput Biol. 16(10)

Kim Y, Wiehe T (2008)
Simulation of DNA sequence evolution under models of recent directional selection
Brief Bioinform. 10(1)

Haubold B, Domazet-Loso M, Wiehe T (2008)
An alignment-free distance measure for closely related genomes
Lecture Notes in Computer Science: Lecture Notes in Bioinformatics, Vol. 5267, Nelson, C.; Vialette, S. (Eds.) 2008, X, 265 p., Springer Berlin. Abstract

Teschke M, Mukabayire O, Wiehe T, Tautz D (2008)
Identification of selective sweeps in closely related populations of the house mouse based on microsatellite scans
Genetics. 180:1537-1545

Živkovi D, Wiehe T (2008)
Second order moments of segregating sites under variable population size
Genetics. 180:341-357

Stephan M, Möller F, Wiehe T, Kleffe J (2007)
Self-alignments to detect mutually exclusive exon usage
In Silico Biol. 7(6):613-621

IVukusic I, Nagaraja Grellscheid S, Wiehe T (2007)
Applying genetic programming to the prediction of alternative mRNA splice variants
Genomics. 89(4):471-479

Thomas M, Möller F, Wiehe T, Tautz D (2007)
A pooling approach to detect signatures of selective sweeps in genome scans using microsatellites
Mol Ecol Notes. 7(3)

Wiehe T, Nolte V, Živkovi D, Schlötterer C (2007)
Identification of selective sweeps using a dynamically adjusted number of linked microsatellites
Genetics. 175(1)

Haubold B, Wiehe T (2006)
How repetitive are genomes?
BMC Bioinformatics. 7:541

Pierstorff N, Bergman C, Wiehe T (2006)
Identifying cis-regulatory modules by combining comparative and compositional analysis of DNA
Bioinformatics. 22(23)

Haubold B, Wiehe T (2006)
Introduction to Computational Biology. An Evolutionary Approach.
Textbook, 328p. Birkhauser, Basel. Link

Haubold B, Piersdorff N, Möller F, Wiehe T (2005)
Genome comparison without alignment using shortest unique substrings
BMC Bioinformatics. 6(123)

Thomas M, Ihle S, Ravaoarimanana I, Krächter S, Wiehe T, Tautz D (2005)
Microsatellite variability in wild populations of the house mouse is not influenced by differences in chromosomal recombination rates
Biol J Linn Soc Lond. 84(3)