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Recent Publications

Jabbari K, Wirtz J, Rauscher M, Wiehe T (2019)
A common genomic code for chromatin architecture and recombination landscape
In press, PlosOne

Wirtz J, Rauscher M, Wiehe T (2018)
Topological linkage disequilibrium calculated from coalescent genealogies
Theor Popul Biol 2018 Sep

Jabbari K et al. (2018)
Rare gene deletions in genetic generalized and rolandic epilepsies
PloS One 13(8):e0202022

Zheng Y, Graur D, Azevedo RBR (2018)
Correlated Selection on Amino Acid Deletion and Replacement in Mammalian Protein Sequences
J Mol Evol. doi:10.1007/s00239-018-9853-9

Ferretti L, Klassmann A, Raineri E, Ramos-Onsins SE, Wiehe T, Achaz G (2018)
The neutral frequency spectrum of linked sites
Theor Popul Biol. 2018 Sep;123:70-79

Thier K, Möckel M, Palitzsch K, Döhner K, Sodeik B, Knebel-Mörsdorf D (2018)
Entry of Herpes Simplex Virus 1 into Epidermis and Dermal Fibroblasts is Independent of the Scavenger Receptor MARCO
J Virol. 2018 May 16. pii: JVI.00490-18

Klassmann A, Ferretti L (2018)
The third moments of the site frequency spectrum
Theor Popul Biol. 2018 Mar;120:16-28

Yang Y, Li J, Wiehe T, Li H (2018)
Detecting recent positive selection with a single locus test bi-partitioning the coalescent tree
Genetics 208(4)

Jabbari K, Heger P, Sharma R, Wiehe T (2018)
The diverging routes of BORIS and CTCF: An interactomic and phylogenomic analysis
Life, 8(1), 4

Bobbili D, Lal D, May P, Reinthaler E, Jabbari K, Thiele H, Nothnagel M, Jurkowski W, Feucht M, Nürnberg P, Lerche H, Zimprich F, Krause R,  Neubauer B, Reinthaler E, Zimprich F, Feucht M , Steinböck H, Neophytou B, Geldner J, Gruber-Sedlmayr U, Haberlandt E, Ronen G, Altmüller J, Sander T, Thiele H, Krause R, May P, Balling R,  Neubauer B (2018)
Exome-wide analysis of mutational burden in patients with typical and atypical Rolandic epilepsy
Eur J Hum Genet;26(2)

Zheng Y, Janke A. (2018)
Gene flow analysis method, the D-statistic, is robust in a wide parameter space
BMC Bioinformatics 19(10), doi:10.1186/s12859-017-2002-4

Nilsson MA, Zheng Y, Kumar V, Phillips MJ, Janka A. (2018)
Speciation Generates Mosaic Genomes in Kangaroos
Genome Biol Evol 10 (1):33-44

Suurväli J, Boudinot P, Kanellopoulos J, Boudinot SR (2017)
P2X4: A fast and sensitive purinergic receptor
Biomedical Journal 40(5)

Venter P-C, Nitsche F, Domonell A, Heger P, Arndt H (2017)
The Protistan Microbiome of Grassland Soil: Diversity in the Mesoscale
Protist 168(5)

Ferretti L, Ledda A, Wiehe T, Achaz G, Ramos-Onsins SE (2017)
Decomposing the Site Frequency Spectrum: The Impact of Tree Topology on Neutrality Tests
Genetics, q-bio.GN 

Older Publications

Pauli T, Vedder L, Dowling D, Petersen M, Meusemann K, Donath A, Peters RS, Podsiadlowski Mayer LC, Liu S, X. Zhou, Heger P, Wiehe T, Hering L, Mayer G, Misof B, Niehuis O (2016)
Transcriptomic data from panarthropods shed new light on the evolution of insulator binding proteins in insects
BMC Genomics, 17:861 

Schiffer P, Gravemeyer J, Rauscher M, Wiehe T (2016)
Ultra large gene families: a matter of adaptation or genomic parasites?
Life 2016, 6(3),32

Kraemer-Eis A, Ferretti L, Schiffer P, Heger P, Wiehe T (2016)
A catalogue of Bilaterian-specific genes - their function and expression profiles in early development

Howe K, Schiffer PH, Zielinski J, Wiehe T, Laird GK, Marioni J, Soylemez O, Kondrashov F, Leptin M (2016)
Structure and evolutionary history of a large family of NLR proteins in the zebrafish
Open Biol. 2016 6

Disanto F, Wiehe T (2014)
On the sub-permutations of pattern avoiding permutations
Discrete Mathematics 337:127

Rafajlovic M, Klassmann A, Eriksson A, Wiehe T, Mehlig B (2014)
Demography-adjusted tests of neutrality based on genome-wide SNP data
Theor. Pop. Biol. 95:1

Heger P, Wiehe T (2014)
New tools in the box: an evolutionary synopsis of chromatin insulators.
Trends in Genetics 30(5):161-71

Schiffer PH, Kroiher M, Kraus C, Koutsovoulos GD, Kumar S, Camps JI, Nsah NA, Stappert D, Morris K, Heger P, Altmüller J, Frommolt P, Nürnberg P, Thomas WK, laxter ML, Schierenberg E (2013)
The genome of Romanomermis culicivorax: revealing fundamental changes in the core developmental genetic toolkit in Nematoda.
BMC Genomics. 14:923.

Disanto F, Schlizio A, Wiehe T (2013)
Yule-generated trees constrained by node imbalance
Math Biosci 246:139–147

Heger P, George R, Wiehe T (2013)
Successive gain of insulator proteins in arthropod evolution
Evolution 67:2945–2956

Li H, Wiehe T (2013)
Coalescent tree imbalance and a simple test for selective sweeps based on microsatellite variation
Plos Comput Biol. 9(5):e1003060

Ferretti L, Disanto F, Wiehe T (2013)
The effect of single recombination events on coalescent tree height and shape
PloS One 8(4):e60123

Disanto F, Wiehe T (2013)
Exact enumeration of cherries and pitchforks in ranked trees under the coalescent model
Math Biosci. 242:195-2004pp

Heger P, Marin B, Bartkuhn M, Schierenberg E, Wiehe T (2012)
The chromatin insulator CTCF and the emergence of metazoan diversity
PNAS 109:17507

Disanto F, Wiehe T (2012)
Some instances of a sub-permutation problem on pattern avoiding permutations

Uhrig S, Coutelle O, Wiehe T, Perabo L, Hallek M, Büning H (2011)
Successful target cell transduction of capsid-engineered rAAV vectord requires clathrin-dependent endocytosis
Gene Ther. 19(2)

Richardson D, Wiehe T (2009)
Properties of sequence conservation in upstream regulatory and protein coding regions among paralogs in Arabidopsis thaliana
Lecture Notes in Computer Science: Lecture Notes in Bioinformatics, Vol. 5817, Ciccarelli, F.; Miklos, I. (Eds.) 2009, Springer Berlin. Abstract

Haubold B, Pfaffelhuber P, Domazet-Loso D, Wiehe T (2009)
Estimating mutation distances from unaligned genomes
J Comput Biol. 16(10)

Kim Y, Wiehe T (2008)
Simulation of DNA sequence evolution under models of recent directional selection
Brief Bioinform. 10(1)

Haubold B, Domazet-Loso M, Wiehe T (2008)
An alignment-free distance measure for closely related genomes
Lecture Notes in Computer Science: Lecture Notes in Bioinformatics, Vol. 5267, Nelson, C.; Vialette, S. (Eds.) 2008, X, 265 p., Springer Berlin. Abstract

Teschke M, Mukabayire O, Wiehe T, Tautz D (2008)
Identification of selective sweeps in closely related populations of the house mouse based on microsatellite scans
Genetics. 180:1537-1545

Živkovi D, Wiehe T (2008)
Second order moments of segregating sites under variable population size
Genetics. 180:341-357

Stephan M, Möller F, Wiehe T, Kleffe J (2007)
Self-alignments to detect mutually exclusive exon usage
In Silico Biol. 7(6):613-621

IVukusic I, Nagaraja Grellscheid S, Wiehe T (2007)
Applying genetic programming to the prediction of alternative mRNA splice variants
Genomics. 89(4):471-479

Thomas M, Möller F, Wiehe T, Tautz D (2007)
A pooling approach to detect signatures of selective sweeps in genome scans using microsatellites
Mol Ecol Notes. 7(3)

Wiehe T, Nolte V, Živkovi D, Schlötterer C (2007)
Identification of selective sweeps using a dynamically adjusted number of linked microsatellites
Genetics. 175(1)

Haubold B, Wiehe T (2006)
How repetitive are genomes?
BMC Bioinformatics. 7:541

Pierstorff N, Bergman C, Wiehe T (2006)
Identifying cis-regulatory modules by combining comparative and compositional analysis of DNA
Bioinformatics. 22(23)

Haubold B, Wiehe T (2006)
Introduction to Computational Biology. An Evolutionary Approach.
Textbook, 328p. Birkhauser, Basel. Link

Haubold B, Piersdorff N, Möller F, Wiehe T (2005)
Genome comparison without alignment using shortest unique substrings
BMC Bioinformatics. 6(123)

Thomas M, Ihle S, Ravaoarimanana I, Krächter S, Wiehe T, Tautz D (2005)
Microsatellite variability in wild populations of the house mouse is not influenced by differences in chromosomal recombination rates
Biol J Linn Soc Lond. 84(3)